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Hearing you or a loved one has stage 3 breast cancer can lead to many questions — about diagnosis, survival, treatments, and more. The first thing to know is that stage 3 breast cancer means the cancer has spread beyond the tumor. Doctors have previously divided stage 3 into more specific categories 3A, 3B, and 3C and the cancer subtype, meaning which type of breast cancer you have. The breast cancer type describes how a cancer grows and what treatments are likely to be most effective. In , the American Joint Committee on Cancer AJCC released updated staging definitions for this type of breast cancer that include biological factors such as tumor grade to better clarify the situation.
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Triple-Negative Breast Cancer: Overview, Treatment, and More
Not all breast cancers are the same. Understand what type of breast cancer you have and how it differs from other types of breast cancer. Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor. Using a tissue sample from your breast biopsy or using your tumor if you've already undergone surgery, your medical team determines your breast cancer type.
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Stage 3 Breast Cancer: Understanding Your Outlook
The cells test "negative" on all 3 tests. These cancers tend to be more common in women younger than age 40, who are African-American, or who have a BRCA1 mutation. Triple-negative breast cancer differs from other types of invasive breast cancer in that they grow and spread faster, have limited treatment options, and a worse prognosis outcome. Once a breast cancer diagnosis has been made using imaging tests and a biopsy , the cancer cells will be checked for certain features. If the cells do not have estrogen or progesterone receptors, and also do not make too much of the HER2 protein, the cancer is considered to be triple-negative breast cancer.
Triple-negative breast cancer is cancer that tests negative for estrogen receptors, progesterone receptors, and excess HER2 protein. These results mean the growth of the cancer is not fueled by the hormones estrogen and progesterone, or by the HER2 protein. So, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2 protein receptors. Still, other medicines are used to successfully treat triple-negative breast cancer. For doctors and researchers, there is intense interest in finding new medications that can treat this kind of breast cancer.