Sex meeting in mito

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The student exchange between Anaheim and Mito, Japan began in Many students have found this to be a life changing experience:. This trip was amazing. Thank you to everybody who worked behind the scenes to make this possible from the chaperones, to the people at the Mito International Center, to the host families, and more.
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Mito-Nuclear Interaction Effects

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The evolution of sex: A new hypothesis based on mitochondrial mutational erosion

We hypothesize that the mutational dynamics of the mitochondrial genome would have favoured the evolution of sexual reproduction. Mitochondrial DNA mtDNA exhibits a high mutation rate across most eukaryote taxa, and several lines of evidence suggest that this high rate is an ancestral character. We propose that negative metabolic effects linked to mitochondrial mutation accumulation would have invoked selection for sexual recombination between divergent host nuclear genomes in early eukaryote lineages. This would provide a mechanism by which recombinant host genotypes could be rapidly shuffled and screened for the presence of compensatory modifiers that offset mtDNA-induced harm.
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The evolution of sex: A new hypothesis based on mitochondrial mutational erosion

Our research in this area mainly relates to mitochondrial malfunction, leading to disease in humans and animals, including myopathies, neuropathies, metabolic diseases, and infertility. We have developed experimental systems, so-called Drosophila mitolines , that allow us to quantify the health and fitness effects of different pairings of mitochondrial and nuclear genomes. The resulting data have substantial bearing on the recently introduced mitochondrial replacement therapy, where nuclear DNA is placed into unrelated mitochondrial surroundings.
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